International Journal of Physics, Chemistry, Mathematics and Biology

Panchakarma, a foundational Ayurvedic detoxification and rejuvenation therapy, is increasingly being examined through the lens of modern redox biology. Cellular oxidative stress arises when excessive reactive oxygen and nitrogen species (ROS, RNS) exceed antioxidant defenses, leading to lipid peroxidation, DNA damage, protein oxidation, and accelerated cellular ageing. This paper explores the influence of Panchakarma on oxidative stress and antioxidant activity by integrating classical Ayurvedic principles with contemporary biochemical evidence. Experimental, animal, and clinical studies consistently report reductions in oxidative biomarkers such as ROS, RNS, and malondialdehyde (MDA), alongside increases in key antioxidant indicators including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), and total antioxidant capacity. Although methodological variations limit cross-study comparability, the overall trend indicates that Panchakarma modulates redox homeostasis through detoxification, metabolic regulation, and enhancement of intrinsic antioxidant responses. These findings support the therapeutic potential of Panchakarma in conditions associated with oxidative imbalance and highlight the need for standardized protocols and biomarker-based monitoring. Further research may clarify mechanistic pathways and optimize Panchakarma-based interventions for clinical and wellness applications..